VU591 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

VU591 HydroHClide 是一种选择性肾外髓质钾通道 (Kir1.1, ROMK) 拮抗剂 (IC50：0.24 μM)。被认为可以阻断 Kir1.1 通道的细胞内孔。在浓度高达 10 μM 时对 Kir7.1 没有影响；不抑制 Kir2.1、Kir2.3 或 Kir4.1。

VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50：0.24 μM).?Thought to block the intracellular pore of the Kir1.1 channel.?Exhibits no effect on Kir7.1 at concentrations up to 10 μM;?does not inhibit Kir2.1, Kir2.3 or Kir4.1.?Displays similar potency to VU 590?.

VU591 hydrochloride is a selective ROMK inhibitor and a ROMK channel pore blocker. VU591 can bind serum protein and has high metabolic stability.

VU591 hydrochloride (i.c.v.; 1.842 μg) significantly decreases the immobile time in TST. Animal Model:Male ICR miceDosage:1.842 μg Administration:i.c.v.; 1.842 μg Result:Showed antidepressive effect in the tail suspension test (TST).

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Cell Cycle/DNA Damage

Potassium Channel

Kir1.1

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1315380-70-1

404.76

C16H13ClN6O5

>98% (HPLC)

DMSO:16 mg/mL (39.53 mM; Need ultrasonic)

Cl.[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1

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(-20℃)

With Ice Pack

≥ 2 years