FG 7142

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FG 7142 还可调节表达 α1 亚基的 GABAA 受体上 GABA 诱导的氯离子通量 (EC50= 137 nM)。 FG 7142 可增加酪氨酸羟基化并导致小鼠大脑皮层 β-肾上腺素受体上调。 FG 7142 是一种非选择性苯二氮卓反向激动剂，对含有 α1 亚基的 GABAA 受体具有高亲和力 (Ki=91 nM)。

FG 7142?also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM).?FG 7142?can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex.?FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM).?FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits.FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively.?FG-7142 (intraperitoneal injection;?15 mg/kg) increases tyrosine hydroxylase activity and dopamine turnover in the medial prefrontal cortex and ventral tegmentum in vivo, but effects are not detected in mesolimbic or nigrostriatal areas.FG-7142 (intraperitoneal injection; 15-30 mg/kg) activates mesolimbocortical dopaminergic projections, leading to increases in dopamine in the prefrontal cortex and the nucleus accumbens in rats.

FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively.FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits (EC50: α2= 507 nM,α3=1.021μM , α5=1.439 μM).

FG-7142 (intraperitoneal?injection; 15-30 mg/kg) activates mesolimbocortical dopaminergic projections, leading to increases in dopamine in the prefrontal cortexandthe nucleus accumbens in rats. FG-7142 (intraperitoneal?injection; 15 mg/kg) increases tyrosine hydroxylase activity and dopamine turnover in the medial prefrontal cortex and ventral tegmentum in vivo, but effects are not detected in mesolimbic or nigrostriatal areas.

ZK 39106,LSU-65

Others

Other Targets

GABAA receptor

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78538-74-6

225.25

C13H11N3O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (443.95 mM)

CNC(=O)c1cc2c(cn1)[nH]c1ccccc21

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(-20℃)

With Ice Pack

≥ 2 years