A-3 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

A-3 盐酸盐是一种有效的、细胞渗透性的、可逆的、ATP 竞争性的、多种激酶的非选择性拮抗剂。 A-3 盐酸盐还抑制 PKC 和酪蛋白激酶 I，Ki 值分别为 47 μM 和 80 μM[1]。 A-3 盐酸盐针对 PKA (Ki=4.3 μM)、酪蛋白激酶 II (Ki=5.1 μM) 和肌球蛋白轻链激酶 (MLCK) (Ki=7.4 μM)。

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively. A-3 hydrochloride against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM).A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM, and it is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively.

A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A-3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively.

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Metabolic Enzyme/Protease

Casein Kinase

CK1|CK2|PKC|PKA

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78957-85-4

321.22

C12H14Cl2N2O2S

>98% (HPLC)

DMSO:125 mg/mL (389.14 mM; Need ultrasonic)

Cl.NCCNS(=O)(=O)c1cccc2c(Cl)cccc12

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(-20℃)

With Ice Pack

≥ 2 years