Miquelianin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Quercetin-3-O-glucuronide 是一种有效的二苯乙烯氧化酶抑制剂，具有抗氧化、抗动脉粥样硬化和抗炎活性。体外研究表明，miquelianin 能够从小肠到达中枢神经系统。

Quercetin-3-O-glucuronide is a potent stilbene oxidase inhibitor, it has antioxidant, anti-atherogenic, and anti-inflammatory activities.In vitro studies indicate that miquelianin is able to reach the central nervous system from the small intestine. Miquelianin shows an antioxidant effect in human plasma. At 50 μM, miquelianin suppresses the consumption of the three antioxidants lycopene, β-carotene, and α-tocopherol significantly. Miquelianin significantly reduces the generation of β-amyloid (Aβ) peptides by primary neuron cultures generated from the Tg2576 AD mouse model. It is also capable of interfering with the initial protein-protein interaction of Aβ1–40 and Aβ1–42. Treatment with 0.1 μM miquelianin suppresses ROS generation, cAMP and RAS activation, phosphorylation of ERK1/2 and the expression of HMOX1, MMP2, and MMP9 genes. Miquelianin suppresses invasion of MDA-MB-231 breast cancer cells and MMP-9 induction and inhibits the binding of [3H]-NA to b2-AR.Miquelianin treatment, compared to vehicle-control treatment, significantly improves AD-type deficits in hippocampal formation basal synaptic transmission and long-term potentiation.

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Quercetin 3-O-glucuronide,Quercetin 3-glucuronide

Others

Other Targets

stilbene oxidase

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22688-79-5

478.36

C21H15O13

>98% (HPLC)

DMSO:30 mg/mL (62.71 mM)

O[C@H]1[C@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)c(O)c2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years