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Zoliflodacin
CAS No. 1620458-09-4
Zoliflodacin ( ETX0914,AZD0914 )
产品货号. M22420 CAS No. 1620458-09-4
Zoliflodacin (ETX0914、AZD0914) 是一种新型细菌 DNA 旋转酶/拓扑异构酶抑制剂。 Zoliflodacin 对革兰氏阳性和革兰氏阴性生物体（包括金黄色葡萄球菌）具有有效的体外抗菌活性（MIC90：0.25 μg/mL）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2499 | 有现货 |
|
| 10MG | ￥3791 | 有现货 |
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| 25MG | ￥5933 | 有现货 |
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| 50MG | ￥8119 | 有现货 |
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| 100MG | ￥10530 | 有现货 |
|
| 500MG | ￥21150 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥2613 | 有现货 |
|
生物学信息
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产品名称Zoliflodacin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Zoliflodacin (ETX0914、AZD0914) 是一种新型细菌 DNA 旋转酶/拓扑异构酶抑制剂。 Zoliflodacin 对革兰氏阳性和革兰氏阴性生物体（包括金黄色葡萄球菌）具有有效的体外抗菌活性（MIC90：0.25 μg/mL）。
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产品描述Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).Zoliflodacin has antibacterial activity against key Gram-positive, fastidious Gram-negative (Haemophilus influenzae, Neisseria gonorrhoeae), atypical (Legionella pneumophila), and anaerobic (Clostridium difficile) bacterial species, including isolates with known resistance to fluoroquinolones. Zoliflodacin stabilizes and arrests the cleaved covalent complex of gyrase with double-strand broken DNA under permissive conditions and thus blocks religation of the double-strand cleaved DNA to form fused circular DNA.
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体外实验——
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体内实验——
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同义词ETX0914,AZD0914
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通路Cell Cycle/DNA Damage
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靶点Topoisomerase
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受体Topoisomerase| DNA gyrase
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研究领域Infection
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适应症Gonorrhoea
化学信息
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CAS Number1620458-09-4
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分子量487.44
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分子式C22H20FN5O7
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纯度>98% (HPLC)
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溶解度DMSO:135 mg/mL (276.95 mM; Need ultrasonic)
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SMILES[H][C@]12[C@H](C)O[C@H](C)CN1c1c(CC22C(=O)NC(=O)NC2=O)cc2c(noc2c1F)N1[C@@H](C)COC1=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Huband MD, et al. In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria. Antimicrob Agents Chemother. 2015 Jan;59(1):467-74.
