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TMBIM6 antagonist-1
CAS No. 123134-61-2
TMBIM6 antagonist-1 ( BIA )
产品货号. M22371 CAS No. 123134-61-2
TMBIM6antagonist-1 是 TMBIM6 的拮抗剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥939 | 有现货 |
|
| 5MG | ￥1511 | 有现货 |
|
| 10MG | ￥2442 | 有现货 |
|
| 25MG | ￥3953 | 有现货 |
|
| 50MG | ￥5515 | 有现货 |
|
| 100MG | ￥7371 | 有现货 |
|
| 500MG | ￥14670 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TMBIM6 antagonist-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TMBIM6antagonist-1 是 TMBIM6 的拮抗剂。
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产品描述TMBIM6 antagonist-1 is an antagonist of TMBIM6.
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体外实验Cell Viability Assay Cell Line:HT1080, MCF7, MDA-MB-2341 and SKBR3 cells.Concentration:0.5-10 μM.Incubation Time:3 days.Result:Inhibited cell viability.Western Blot Analysis Cell Line:WT and TMBIM6 KO HT1080 cells.Concentration:0, 2, 5 μM.Incubation Time:Result:Downregulated the protein levels of AKT-pS473.
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体内实验Animal Model:Six- to eight-week BklNbt:BALB/c/nu/nu old mice (HT1080 and MDA-MB-231 cells).Dosage:1?mg/kg.Administration:IP 5 days per week during 25 days.Result:Impaired cell-driven tumor growth.
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同义词BIA
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通路PI3K/Akt/mTOR signaling
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靶点mTOR
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受体TMBIM6
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研究领域——
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适应症——
化学信息
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CAS Number123134-61-2
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分子量268.27
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分子式C15H12N2O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 50 mg/mL (186.38 mM)
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SMILESNc1ccccc1C(=O)\C=C\c1cccc(c1)[N+]([O-])=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Kim H K , Bhattarai K R , Junjappa R P , et al. TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation[J]. Nature Communications, 2020, 11(1).
