(S,R,S)-AHPC-PEG3-N3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(S,R,S)-AHPC-PEG3-N3 是一种合成的 E3 连接酶配体-连接子缀合物，其中包含 PROTAC 技术中使用的基于 (S,R,S)-AHPC 的 VHL 配体和 3 单元 PEG 连接子。

(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker.

(S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker.

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VH032-PEG3-N3

PROTACs

PROTAC

VHL

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1797406-80-4

645.77

C30H43N7O7S

>98% (HPLC)

DMSO:50 mg/mL (77.43 mM; Need ultrasonic)

O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCN=[N+]=[N-]

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(-20℃)

With Ice Pack

≥ 2 years