Gluten Exorphin C

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

麸质外啡肽 C 是一种源自小麦麸质的阿片肽。在 GPI 和 MVD 测定中，μ 阿片类化合物和 δ 阿片类化合物活性的 IC50 值分别为 40 μM 和 13.5 μM。 麸质外啡肽 C 是从小麦面筋的胃蛋白酶-胰蛋白酶-胰凝乳蛋白酶消化物中分离出来的，被认为是 δ-阿片类受体-选择性配体。

Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.Gluten Exorphin C, isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten, was considered as a δ-opioid receptor-selective ligand.Gluten exorphin C, a novel opioid peptide, is isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten. Gluten exorphin C is evaluated its opioid activities by the GPI and MVD assays and its receptor affinities by radioreceptor assays. Its IC50s are 40 μM and 13.5 μM in the GPI and the MVD assays, respectively. Gluten exorphin C has a structure quite different from any of the endogenous and exogenous opioid peptides ever reported in that the N terminal Tyr is the only aromatic amino acid. The analogs containing Tyr-Pro-X-Ser-Leu are synthesized to study its structure-activity relationship. Peptides in which X is an aromatic amino acid or an aliphatic hydrophobic amino acid has opioid activity.

Gluten exorphin C, a novel opioid peptide, is isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten.Gluten exorphin C is evaluated its opioid activities by the GPI and MVD assays and its receptor affinities by radioreceptor assays. Its IC50s are 40 μM and 13.5 μM in the GPI and the MVD assays, respectively. Gluten exorphin C has a structure quite different from any of the endogenous and exogenous opioid peptides ever reported in that the N terminal Tyr is the only aromatic amino acid. The analogs containing Tyr-Pro-X-Ser-Leu are synthesized to study its structure-activity relationship. Peptides in which X is an aromatic amino acid or an aliphatic hydrophobic amino acid has opioid activity.

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Endocrinology/Hormones

Opioid Receptor

δ-opioid receptor|μ-opioid receptor

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142479-62-7

591.7

C29H45N5O8

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (169.00 mM)

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years