GMQ hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GMQ 盐酸盐是一种有效的选择性酸敏感离子通道 (ASIC) 调节剂。

GMQ hydrochloride is a potent and selective acid-sensing ion channel (ASIC) modulator.?It activates ASIC3 channels under neutral pH and blocks acid-induced maximal peak current.Addition of GMQ to pituitary GH3 cells raised the amplitude of Ca2+-activated K+ currents (IK(Ca)), which was reversed by verruculogen or PF1022A, but not by TRAM-39.?Under inside-out current recordings, addition of GMQ into bath enhanced the probability of large-conductance Ca2+-activated K+ (BKCa) channels with an EC50 value of 0.95 M. The activation curve of BKCa channels during exposure to GMQ shifted to a lower depolarized potential, with no change in the gating charge of the curve;?however, there was a reduction of free energy for channel activation in its presence.?As cells were exposed to GMQ, the amplitude of ion currents were suppressed, including delayed rectifying K+ current, voltage-gated Na+ and L-type Ca2+ currents.?In Rolf B1.T olfactory sensory neuron, addition of GMQ was able to induce inward current and to suppress peak INa.?

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NSC 403387 hydrochloride

Others

Other Targets

ion channel (ASIC)

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5361-15-9

237.69

C10H12ClN5

>98% (HPLC)

In Vitro:?H2O : 3.33 mg/mL (14.01 mM)

CC1=NC(NC(N)=N)=NC2=C1C=CC=C2.Cl

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(-20℃)

With Ice Pack

≥ 2 years