Benzonatate ( —— )

产品货号. M22185 CAS No. 104-31-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Benzonatate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

苯佐那酯是钠通道蛋白的拮抗剂。含有 9-乙氧基成分的苯佐那酯组分对 Na(+) 电流的抑制最为有效。
产品描述

Benzonatate is an antagonist of sodium channel protein.Na(+) currents are inhibited most potently by a benzonatate fraction containing the 9-ethoxy component.?Detectable effects of benzonatate occur at concentrations as low as 0.3 μM, which has been reported in humans. benzonatate has local anesthetic-like effects on voltage-gated sodium channels, including Nav1.7, which is a possible mechanism for cough suppression by the drug.
体外实验

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体内实验

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同义词

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通路

Membrane Transporter/Ion Channel
靶点

Sodium Channel
受体

sodium channel
研究领域

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适应症

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1.Evans M S , Maglinger G B , Fletcher A M , et al. Benzonatate inhibition of voltage-gated sodium currents[J]. Neuropharmacology, 2016, 101:179.

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