Mal-amido-PEG4-NHS ester

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Mal-amido-PEG4-NHS 酯是一种基于 PEG 的 PROTAC 连接体，可用于 PROTAC 的合成。 PROTAC 包含两个通过连接体连接的不同配体；一个是 E3 泛素连接酶的配体，另一个是靶蛋白的配体。

Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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PROTACs

PROTAC

PEGs|Alkyl/ether

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756525-99-2

513.5

C22H31N3O11

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (194.74 mM)

O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

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(-20℃)

With Ice Pack

≥ 2 years