2',5'-Dideoxyadenosine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

2',5'-Dideoxyadenosine 是一种有效的非竞争性腺苷酸环化酶抑制剂，通过结合 P 位点 (IC50: 3 μM)。2',5'-Dideoxyadenosine (20-150 mM) 与腺苷一样，具有依赖性和可逆性抑制异丙肾上腺素 (8-54 pmol) β-肾上腺素能刺激的正性肌力和变时作用，分别高达 70% 和 50%。

2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3].2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) fully inhibits the natriuretic, diuretic and K+ and Cl- sparing effect of FrEtOAc in rats.

Western Blot Analysis Cell Line:Primary hippocampal neurons Concentration:10 μM Incubation Time:30 min Result:Reduced cAMP production and blocked the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).

Animal Model:Male Wistar rats (3-4 months old)Dosage:0.1 mg/kg Administration:IP; 15 min pre-treated Result:Fully inhibited the diuretic, natriuretic and K+ and Cl- sparing effect of Fr?EtOAc in rats.

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Others

Other Targets

Adenylyl cyclase (AC)

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6698-26-6

235.24

C10H13N5O2

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (531.37 mM)

C[C@H]1O[C@H](C[C@@H]1O)n1cnc2c(N)ncnc12

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(-20℃)

With Ice Pack

≥ 2 years