TBOPP ( —— )

产品货号. M22123 CAS No. 1996629-79-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

TBOPP
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

TBOPP 是一种选择性 DOCK1 抑制剂 (IC50 : 8.4 μM)，对更广泛的肿瘤类型具有抗肿瘤活性。
产品描述

TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors. TBOPP as a selective inhibitor of DOCK1.?TBOPP dampened DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins.TBOPP treatment suppressed cancer metastasis and growth in vivo in mice.
体外实验

Cell Viability Assay Cell Line:3LL cells Concentration:12.5 μM Incubation Time:3 days Result:Inhibited cell viability.
体内实验

Animal Model:C57BL/6 mice (6- to 8-week-old) with ex-3LL cells Dosage:0.67 mg per mouse Administration:Administrated on days 0, 1, 3, and 5; for 2 weeks Result:The lung metastasis was significantly suppressed.
同义词

——
通路

Others
靶点

Other Targets
受体

DOCK1|DOCK1 DHR-2 domain
研究领域

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适应症

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1.Tajiri H, et al. Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCKCell Rep. 2017 May 2;19(5):969-980.

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