FEN1 Inhibitor C2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FEN1-IN-4 是人皮瓣核酸内切酶 1 (hFEN1) 的抑制剂。FEN1 抑制剂 C2 抑制选择性损害缺乏 Cdc4 和 Mre11a 的结肠癌细胞的增殖，这两种细胞在结直肠癌中经常发生突变。

FEN1-IN-4 is an inhibitor of human flap endonuclease-1 (hFEN1)FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.?FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate)-induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines.

FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.

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FEN1-IN-4

Others

Other Targets

hFEN1

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1995893-58-7

232.24

C12H12N2O3

>98% (HPLC)

DMSO:100 mg/mL (430.59 mM; Need ultrasonic)

On1c(=O)n(CC2CC2)c2ccccc2c1=O

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(-20℃)

With Ice Pack

≥ 2 years