Metformin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

二甲双胍是一种 AMP 激活蛋白激酶 (AMPK) 激活剂，可通过提高胰岛素敏感性和减少肠道对葡萄糖的吸收来改善血糖控制。

Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.Metformin is a first-line drug for the treatment of type 2 diabetes (T2D) and is often prescribed in combination with other drugs to control a patient's blood glucose level and achieve their HbA1c goal.(In Vitro):Metformin (1,1-Dimethylbiguanide) inhibits proliferation of ESCs in a concentration-dependent manner. The IC50 is 2.45?mM for A-ESCs and 7.87?mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase.Metformin (0-500 μM) decreases glycogen synthesis in a dose-dependent manner with an IC50 value of 196.5 μM in cultured rat hepatocytes.Metformin shows cell viability and cytotoxic effects on PC-3 cells with IC50 of 5 mM.(In Vivo):Metformin (1,1-Dimethylbiguanide; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with isoproterenol groups attenuates myocyte necrosis through histopathological analysis.Metformin (> 900 mg/kg/day, p.o.) results in moribundity/mortality and clinical signs of toxicity in Crl:CD(SD) rats.

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1,1-Dimethylbiguanide

Membrane Transporter/Ion Channel

AMPK

AMPK|Autophagy

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657-24-9

129.16

C4H11N5

>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (387.12 mM)

CN(C)C(=N)NC(N)=N

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(-20℃)

With Ice Pack

≥ 2 years