PAβN dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PAβN diHClide 是一种外排泵抑制剂。 PAβN 降低了 9 种环丙沙星耐药菌株的 MIC，其中 4 种菌株中，PAβN 使敏感性增加了一倍。

PAβN dihydrochloride is an inhibitor of efflux pump. PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold.?Moreover, PAβN restores ciprofloxacin susceptibility in five of the ciprofloxacin-resistant isolates.?In addition, clear effects of NMP on the ciprofloxacin MICs are seen for 20 of these ciprofloxacin-resistant isolates.

PAβN increases the susceptibilities of the three pump-overexpressing mutants of P. aeruginosa to levofloxacin 64-fold. PAβN also potentiates the activity of levofloxacin against strain PAM2391 containing plasmid pAGH97 with the mexXY genes and against wild-type strain PAM1020. PAβN has an effect on susceptibilities to other antibiotics that are substrates of efflux pumps. PAβN increases levels of accumulation of efflux pump substrates inside the cell. It enhances the activity of levofloxacin against clinical isolates of P. aeruginosa. PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold. Moreover, PAβN restores ciprofloxacin susceptibility in five of the ciprofloxacin-resistant isolates. In addition, clear effects of NMP on the ciprofloxacin MICs are seen for 20 of these ciprofloxacin-resistant isolates. PAβN permeabilizes bacterial membranes in a concentration-dependent manner at levels below those typically used in combination studies, and this additional mode of action should be considered when using PAβN as a control for efflux studies.

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MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride

GPCR/G Protein

Antibacterial

Bacterial| efflux pump

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100929-99-5

519.47

C25H32Cl2N6O2

>98% (HPLC)

DMSO:95mg/ml (182.88 Mm);H2O:14.29 mg/mL (27.51 mM; Need ultrasonic)

Cl.Cl.N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1=CC2=CC=CC=C2C=C1

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(-20℃)

With Ice Pack

≥ 2 years