021-51111890
购物车（）
sales@molnova.cn
TED-347
CAS No. 2378626-29-8
TED-347 ( —— )
产品货号. M21960 CAS No. 2378626-29-8
TED-347 是 TEAD4-Yap1 蛋白质-蛋白质相互作用的不可逆共价抑制剂（EC50 为 5.9 μM），并抑制胶质母细胞瘤细胞活力。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1017 | 有现货 |
|
| 10MG | ￥1511 | 有现货 |
|
| 25MG | ￥2762 | 有现货 |
|
| 50MG | ￥4046 | 有现货 |
|
| 100MG | ￥5355 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥847 | 有现货 |
|
生物学信息
-
产品名称TED-347
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述TED-347 是 TEAD4-Yap1 蛋白质-蛋白质相互作用的不可逆共价抑制剂（EC50 为 5.9 μM），并抑制胶质母细胞瘤细胞活力。
-
产品描述TED-347 is an?irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
-
体外实验Cell Viability Assay Cell Line:GBM43 glioblastoma cell lines Concentration:0.5, 1, 10, 100 μM Incubation Time:48 hoursResult:Inhibited GBM43 cancer cell viability and inhibited GBM43 cell viability by 30% at 10 μM.Western Blot Analysis Cell Line:HEK-293 cells Concentration:5 μM Incubation Time:48 hours Result:Showed a significant loss of co-immunoprecipitation of Myc-tagged TEAD4 with FLAG-tagged Yap1.RT-PCRCell Line:HEK-293 cells Concentration:10 μM Incubation Time:48 hours Result:Showed a significant reduction in CTGF transcript levels versus control cells and had no inhibition on TEAD mutant transcriptional activity and protein-protein interactions in cell culture.
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体TEAD4-Yap1
-
研究领域——
-
适应症——
化学信息
-
CAS Number2378626-29-8
-
分子量313.7
-
分子式C15H11ClF3NO
-
纯度>98% (HPLC)
-
溶解度DMSO:64 mg/ml(204.02 mM)
-
SMILESFC(F)(F)c1cccc(Nc2ccccc2C(=O)CCl)c1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD?Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13.
产品手册
关联产品
-
Amylin, amide, human
Amylin, a 37-amino acid polypeptide that is structurally related to calcitonin, is secreted from the B cells of the pancreas. Amylin has anoretic effects in rats. Amylin may be responsible for the etiology of insulin resistance of type II diabetes mellitus through its modulation of peripheral effects of insulin.
-
YNT-185
YNT-185 是一中非肽类的，选择性食欲素 2 型受体 (OX2R) 激动剂，对 OX2R 和 OX1R 的 EC50 分别为 0.028 和 2.75 μM。YNT-185 改善小鼠模型的发作性瘫痪症状。
-
Hydrocinnamic alcoho...
氢化肉桂醇存在于苏合香和蕨香脂中，也存在于越橘属水果、番石榴果实和果皮、黑莓、其他水果、朗姆酒、白葡萄酒、香菇、松茸和泥炭麦芽中。它是一种调味成分。
