CCT018159

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

热休克蛋白 90 (Hsp90) 是一种分子伴侣，可激活和维持多种客户蛋白的生物功能，其中许多与致癌信号通路相关。

The heat shock protein 90 (Hsp90) is a molecular chaperone that activates and maintains the biological functioning of several client proteins, many of which are associated with oncogenic signaling pathways. Its activity is driven by ATP and regulated by co-chaperones such as Hsp72. CCT018159 is a 3,4-diaryl pyrazoloresorcinol compound that inhibits the ATPase activity of Hsp90 with IC50 values of 3.2 and 6.6 μM for human Hsp90β and yeast Hsp90, respectively.At concentrations up to 100 μM, CCT018159 does not inhibit human Hsp72 ATPase or topoisomerase II, yet at 50 μM CCT018159 inhibits 13 out of a panel of 20 commonly studied kinases.

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Others

Other Targets

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171009-07-7

352.4

C20H20N2O4

>98% (HPLC)

DMSO: 30 mg/ml

CCc1cc(c(O)cc1O)c1n[nH]c(C)c1c1ccc2OCCOc2c1

4-[4-(2,3-dihydo-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol

(-20℃)

With Ice Pack

≥ 2 years