Hyperforin dicyclohexylammonium salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hyperforin dicyclohexylammium salt (Hyperforin DCHA) 是一种瞬时受体规范 6 (TRPC6) 通道激活剂。

Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt shows antidepressant effect.

Western Blot Analysis Cell Line:HaCaT cells Concentration:0.1, 1, 10 μM; with or without 10, 20 ng/mL TNF-α Incubation Time:2 hours Result:Reduced the expressions of p-p38, p-ERK, p-JNK, and p-STAT3, especially at the dosage of 10 μM.

Animal Model:IMQ-induced psoriasis-like mice modelDosage:5 mg/kg Administration:Intraperitoneal injection; once daily for 7 days Result:Significantly ameliorated skin lesion throughout the treatment period, demonstrated by the reduced severity score of skin inflammation.Suppressed infiltration of CD3+ T cells and down regulated expression of Il1, Il6, Il23, Il17a, Il22, antimicrobial peptides (AMPs) in the skin lesion.

Hyperforin DCHA

Others

Other Targets

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238074-03-8

718.1

C??H??NO?

>98% (HPLC)

DMSO : 50 mg/mL (69.63 mM; Need ultrasonic)

CC(C)C([C@@]12[C@@](C)([C@H](C[C@](C/C=C(C)/C)(C(C(C/C=C(C)/C)=C2O)=O)C1=O)C/C=C(C)/C)CC/C=C(C)/C)=O.C3(CCCCC3)NC4CCCCC4

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(-20℃)

With Ice Pack

≥ 2 years