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Ro-3306
CAS No. 872573-93-8
Ro-3306 ( —— )
产品货号. M21759 CAS No. 872573-93-8
Ro-3306 是一种有效的选择性 CDK1 抑制剂，对 CDK1、CDK1/cyclin B1 和 CDK2/cyclin E 的 Ki 值分别为 20 nM、35 nM 和 340 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥711 | 有现货 |
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| 10MG | ￥981 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Ro-3306
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Ro-3306 是一种有效的选择性 CDK1 抑制剂，对 CDK1、CDK1/cyclin B1 和 CDK2/cyclin E 的 Ki 值分别为 20 nM、35 nM 和 340 nM。
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产品描述RO-3306 is an ATP-competitive inhibitor, and inhibits CDK1/cyclin A complexes with Ki of 110 nM. RO-3306 blocks the cell cycle in the G2/M phase of human cancer cells. RO-3306 (4 μM) induces apoptosis in cancer cells. RO-3306 (5 μM) induces G2/M-phase cell cycle arrest and apoptosis of AML cells in a time-dependent manner. RO-3306 treatment significantly increases the percentage of Annexin V-positive cells in G1-phase cells without affecting the cell cycle distribution. RO-3306 enhances p53-mediated apoptosis. RO-3306 cooperates with Nutlin-3 in activating Bax and inducing mitochondrial apoptosis. RO-3306 (5 μM) downregulates antiapoptotic p21, Bcl-2 and survivin protein expression in AML. RO-3306 inhibits p53-induced p21 synthesis. RO-3306 does not inhibit RNA polymerase II CTD phosphorylation. RO-3306 (10 μM) effectively arrests oocyte maturation. RO-3306 reduces the blastocyst formation in oocytes.
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体外实验——
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体内实验——
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同义词——
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通路Angiogenesis
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靶点CDK
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number872573-93-8
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分子量351.45
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分子式C??H??N?OS?
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 47 mg/mL (133.73 mM) H2O : < 0.1 mg/mL (insoluble)
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SMILESO=C1N=C(NCC2=CC=CS2)S/C1=C\C3=CC=C4N=CC=CC4=C3
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Vassilev LT, et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10660-5.
2. Kojima K, et al. Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 2009 Jun;100(6):1128-36.
3. Jang WI, et al. A specific inhibitor of CDK1, RO-3306, reversibly arrests meiosis during in vitro maturation of porcine oocytes. Anim Reprod Sci. 2014 Jan 30;144(3-4):102-8.
