LC3-mHTT-IN-AN1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LC3-mHTT-IN-AN1（化合物 AN1）是一种 mHTT-LC3 连接化合物，可与突变型亨廷顿蛋白 (mHTT) 和 LC3B 相互作用，但不与 wtHTT 或不相关的对照蛋白相互作用。 LC3-mHTT-IN-AN1 以等位基因选择性方式降低培养的亨廷顿病 (HD) 小鼠神经元中的 mHTT 水平。

LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.

LC3-mHTT-IN-AN1 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons.

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Autophagy

Autophagy

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486443-73-6

411.04

C??H?Br?NO?

>98% (HPLC)

DMSO : 125 mg/mL (304.11 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O

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(-20℃)

With Ice Pack

≥ 2 years