MMP-9-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MMP-9-IN-1 是特定基质金属蛋白酶-9 (MMP-9) 的抑制剂。

MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).

MMP-9-IN-1 (compound 2; 100 μM; 14 hours) does not cause notable cytotoxicity.MMP-9-IN-1 (compound 2; 10 μM) significantly inhibits cell proliferation of HT-1080 and MDA-MB-435 cells. Cell Cytotoxicity Assay Cell Line:COS-1 monkey epithelial cell lines Concentration:100 μM Incubation Time:24 hours Result:Treatment did not cause notable cytotoxicity. Cell Proliferation Assay Cell Line:HT-1080 and MDA-MB-435 cancer cells expressing endogenous MMP-9Concentration:10 μM Incubation Time:9 days Result:Significant inhibition of cell proliferation.

MMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor. MMP-9-IN-1 inhibits cancer cell metastasis in vivo. Animal Model:4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumorDosage:20 mg/kg Administration:Intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks,Result:Resulted in a profound delay in tumor growth.Inhibited cancer cell metastasis.

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Metabolic Enzyme/Protease

MMP

MMP-9

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502887-71-0

369.39

C16H17F2N3O3S

>98% (HPLC)

DMSO:125 mg/mL (338.40 mM; Need ultrasonic)

CCCc1cc(=O)[nH]c(SCC(=O)Nc2ccc(OC(F)F)cc2)n1

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(-20℃)

With Ice Pack

≥ 2 years