J-14

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

J-14 是一种可逆硫氧还蛋白抑制剂（IC50：8.1 μM）。 J14 通过抑制硫氧还蛋白诱导氧化应激（细胞内 ROS 积累），从而导致细胞毒性和癌细胞死亡。

J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM).?J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin leading to cytotoxicity and cancer cell death.

Cell Viability Assay Cell Line:A549 cells Concentration:0-100 μM Incubation Time:0 hour, 24 hours, 48 hours, 72 hours, 96 hours Result:Inhibited the growth of A549 cells in a concentration- and a time- dependent manner.Western Blot Analysis Cell Line:A549 cells Concentration:20 μM Incubation Time:48 hours, 72 hours Result:Caused not only the release of cytochrome c into the cytosol, but also the activation of caspase-3 and caspase-9.

Animal Model:Six-week-old BALB/c nude female mice injected with A549 cells Dosage:50 mg/kg Administration:Intraperitoneal injection; daily; for 16 days Result:Significantly reduced the growth of human lung tumor without acute toxicity.

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Others

Other Targets

sulfiredoxin

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1043854-13-2

517.04

C28H25ClN4O2S

>98% (HPLC)

DMSO:260 mg/mL (502.86 mM; Need ultrasonic)

OC(=O)c1ccc(CSc2nc(cc(n2)-c2ccccc2)N2CCN(CC2)c2ccccc2Cl)cc1

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(-20℃)

With Ice Pack

≥ 2 years