L-(+)-Ergothioneine ( Ergothioneine )

产品货号. M21510 CAS No. 497-30-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

L-(+)-Ergothioneine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

麦角硫因由某些细菌和真菌合成。它通常被认为是一种抗氧化剂。
产品描述

Ergothioneine is synthesized by certain bacteria and fungi. It is generally considered an antioxidant.
体外实验

Cell Viability Assay Cell Line:PC12 Concentration:0.25, 1 mM Incubation Time:23 h Result:Increased cell viability by approximately 13% and 34%, respectively.Western Blot Analysis Cell Line:PC12 Concentration:0.25, 1 mM Incubation Time:23 h Result:Counteracted the p38 phosphorylation induced by 1 h incubation with H2O2.
体内实验

Animal Model:Cisplatin-treated ratsDosage:70 mg/kg Administration:p.o.Result:Decreased serum creatinine and BUN.Increased GFR at two-fold.Suppressed cisplatin-induced oxidative stress and GCT.Up-regulated the levels of Nrf2, NQO1, and HO-1. Suppresses NF-κB signaling and the pro-inflammatory cytokines.
同义词

Ergothioneine
通路

Others
靶点

Antioxidant
受体

Antioxidant
研究领域

——
适应症

——

CAS Number

497-30-3
分子量

229.3
分子式

C9H15N3O2S
纯度

>98% (HPLC)
溶解度

H2O:125 mg/mL (545.14 mM; Need ultrasonic)
SMILES

C[N+](C)(C)[C@@H](Cc1c[nH]c(=S)[nH]1)C([O-])=O
化学全称

(S)-3-(2-thioxo-23-dihydro-1H-imidazol-4-yl)-2-(trimethylammonio)propanoate

1.Oumari M et al. Regeneration of ergothioneine after reaction with singlet oxygen. Free Radic Biol Med. 2019 Apr;134:498-504.

计算器

产品手册

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