Isoliquiritin apioside

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

从甘草根茎中分离出的异甘草苷 apioside 可显着降低 PMA 诱导的 MMP9 活性增加，并抑制 PMA 诱导的 MAPK 和 NF-κB 激活。

Isoliquiritin apioside isolated from Glycyrrhizae radix rhizome significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells. Isoliquiritin apioside has marked potential to combat oxidative stress-induced genotoxicity.

Isoliquiritin apioside efficiently suppresses the PMA-induced gelatinolytic MMP-9 activity in HT1080 cells. Isoliquiritin apiosidealso decreases the PMA-induced increase in MMP-9 production in HT1080 cells.Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and endothelial cells (ECs), with no cytotoxicity.

——

——

Apoptosis

NF-κB

NF-κB

——

——

120926-46-7

550.5

C26H30O13

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (45.41 mM)

C1[C@@]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC=C(C=C3)/C=C/C(=O)C4=C(C=C(C=C4)O)O)CO)O)O)O)(CO)O

——

(-20℃)

With Ice Pack

≥ 2 years