SPEN-IN-1 binding suppresses histone H3K27 trimethylation and blocks initiation of X-chromosome inactivation. SPEN-IN-1 binding reduces the conformational space of RepA and displaces cognate interacting protein factors including PRC2 and SPEN.

2β-Methoxy-2-deethoxy-8-O-deacylphantomolin-8-O-tiglinate is a sesquiterpene lactone that can be isolated from Elephantopus mollis. 2β-Methoxy-2-deethoxy-8-O-deacylphantomolin-8-O-tiglinate exhibits cytotoxicity in mouse neuroblastoma B104 cells with an IC50 of 3.85 μM.

FEN1-IN-SC13 是 DNA 片段化核酸内切酶 1 (FEN1) 的有效抑制剂。