Ethyl pyruvate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

丙酮酸乙酯是一种简单的丙酮酸脂肪族酯，已被证明通过其抗炎、抗氧化和抗凋亡功能具有强大的神经保护作用。

Ethyl pyruvate is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory anti-oxidative and anti-apoptotic functions.

Cell Viability Assay Cell Line:N9 microglial Concentration:1-100 mM Incubation Time:1 h Result:Did not show cytotoxic effects in the range of 1–10 mM.Western Blot Analysis Cell Line:N9 microglial Concentration:10 mM Incubation Time:1 h Result:Suppressed LPS (HY-D1056)- and ATP (HY-B2176)-induced IL-1β and IL-18 protein and mRNA levels.Reduced NLRP3, Caspase-1, and ASC Specks.Reduced NF-κB activation and HMGB1 expression level.Apoptosis Analysis Cell Line:MC38 Concentration:10, 20, 40 mM Incubation Time: 6, 24 h Result:Induced an increase in autophagy and apoptosis in a dose-and time-dependent manner.

Animal Model:Liver tumor model in miceDosage:80 mg/kg Administration:i.p., 30 min before tumor injection and daily up to 9 days and daily from 7 to 10 days after infusion of tumor cells.Result:Decreased innate immune cells (NK cells, monocytes) and T and B cell lymphocytic infiltrates.Inhibited the release of HMBG1.Animal Model:Paraquat-intoxicated rats Dosage:2 or 40 mg/kg Administration:30 min before or 1 h after paraquat (50 mg/kg i.p.)Result:Decreased the MDA concentrations at 6 and 24 h.Decreased NO concentrations significantly at 6 h and GSH concentrations in the lung.

——

Others

Antioxidant

Antioxidant|Apoptosis

——

——

617-35-6

116.11

C5H8O3

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (861.18 mM)

CCOC(=O)C(C)=O

ethyl 2-oxopropanoate

(-20℃)

With Ice Pack

≥ 2 years