Quinidine sulfate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Quinidine硫酸盐二水合物是一种有效的选择性细胞色素P450db抑制剂。

Quinidine sulfate dihydrate is a potent and selective cytochrome P450db??inhibitor.(In Vitro):Quinidine hydrochloride monohydrate blocks WT mSlo3 (KCa5.1) channels with an IC50 of 19.9±1.41?μM and Hill slope of 1.15±0.15 (n=7). Again, the potency of inhibition by Quinidine hydrochloride monohydrate is higher for F304Y mSlo3 (IC50 of 2.42±0.60?μM, n=9, P<0.005; Hill slope of 0.98±0.12), but lower with R196Q mSlo3 (IC50 of 38.4±6.77?μM, n=5, P<0.001; Hill slope of 1.05±0.16). The inhibition of F304Y mSlo3 by Quinidine hydrochloride monohydrate is observed to have some time dependence.(In Vivo):Direct application of Quinidine hydrochloride monohydrate on the sciatic nerve produces a dose-related decrease in amplitude at ascending somato-sensory evoked potential (SSEP) and descending compound muscle action potentials (CMAP) when comparing baseline with other time points, or when comparing the experimental left limb to the right contra-lateral glucose-treated limb. The latencies of SSEPs and CMAP potentials after Quinidine hydrochloride monohydrate applications are increased compare to baseline and the contralateral side.

Quinidine sulfate dihydrate shows cytotoxicity against MES-SA cells, and induces apoptosis.

Quinidine sulfate dihydrate shows effects on the PTZ-induced seizure threshold. Animal Model:Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)Dosage:10, 20, and 30 mg/kg Administration: Intraperitoneal injection; 10, 20, and 30 mg/kg; once Result:Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).

Quinidine sulfate dihydrate | Chinidin Sodium | Pitayine Sodium | β-quinine Sodium

Metabolic Enzyme/Protease

P450

CYP450

Cardiovascular Disease

Arrhythmia

6591-63-5

782.9

C40H54N4O10S

>98% (HPLC)

DMSO:100 mg/mL (154.12 mM)Ethanol:100 mg/mL (154.12 mM)H2O:9 mg/mL (13.87 mM)

C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12.C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12.O.O.O=S(=O)(O)O

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(-20℃)

With Ice Pack

≥ 2 years