mTOR inhibitor 9a inhibited the growth of human LNCap cells with an ic50 of 80 nm. 1-methyl-3 -{4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl}urea may have antitumor activity.

中间体。

Sepin-1 是分离酶的非竞争性抑制剂，IC50 为 14.8 μM。 Sepin-1可以通过抑制细胞增殖和诱导细胞凋亡来抑制小鼠和人类癌细胞系中乳腺癌异种移植肿瘤的生长。