TH5487

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TH5487 是 8-氧鸟嘌呤 DNA 糖基化酶 1 (OGG1) 的有效抑制剂（IC50 为 342 nM）。

TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM).

RT-PCR Cell Line:Murine airway epithelial cell line (MLE 12); Diploid human small-airway epithelial cell (hSAECs) Concentration:5 μM Incubation Time:1 hour Result:Inhibited proinflammatory gene expression dose-dependently.Western Blot Analysis Cell Line:Murine airway epithelial cell line (MLE 12); Diploid human small-airway epithelial cell (hSAECs)Concentration:2.5 μM; 5 μM; 10 μM Incubation Time:1 hour Result:Decreased p50-p65 and p50-p50 expression in a dose dependent manner.

Animal Model:Eightweek-old female and male BALB/c mice Dosage:8 mg/kg, 15 mg/kg, 30 mg/kg Administration:Prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours Result:Interrupted TNFα-induced ongoing inflammatory processes.

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Others

Other Targets

8-oxoguanine DNA glycosylase 1 (OGG1)

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2304947-71-3

541.18

C19H18BrIN4O2

>98% (HPLC)

DMSO:25 mg/mL (46.20 mM; Need ultrasonic)

O=C(Nc1ccc(I)cc1)N1CCC(n2c(=O)[nH]c3c(Br)cccc32)CC1

4-(4-Bromo-23-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide

(-20℃)

With Ice Pack

≥ 2 years