TFEB activator 1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TFEB activator 1 是转录因子 EB (TFEB) 的激活剂，有望预防或治疗阿尔茨海默病。

TFEB activator 1 is an activator?of transcription factor EB (TFEB) ?with promise for the prevention or treatment of Alzheimer's disease.

Western Blot Analysis Cell Line:N2a cells Concentration:0, 0.2, 0.4, 0.6, 0.8 and 1 μM Incubation Time:12 hours Result:Treatment dose-dependently increased the levels of LC3-II and SQSTM1/p62 (sequestosome 1).

Animal Model:Adult male Sprague-Dawley (SD) rats weighing 350 to 400 gDosage:10 mg/kg and 25 mg/kg Administration:Short-term oral administration; for 24 hoursResult:Activated TFEB and enhanced autophagy and lysosome biogenesis in rat brain. Animal Model:Adult male Sprague-Dawley (SD) rats weighing 350 to 400 g Dosage:10 mg/kg Administration:Chronic oral administration; daily; for 21 days Result:Activated TFEB and enhanced autophagy in rat brains.

(1E4E)-15-Bis(2-Methoxyphenyl)penta-1 | Curcumin analog C1 | Curcumin analog compound C1 | RPN77612

Others

Other Targets

TFEB

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39777-61-2

294.34

C19H18O3

>98% (HPLC)

DMSO:59 mg/mL (200.45 mM)Ethanol:2 mg/mL (6.79 mM)

COc1ccccc1/C=C/C(=O)/C=C/c1ccccc1OC

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(-20℃)

With Ice Pack

≥ 2 years