Aegeline

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Aegeline 是一种生物碱酰胺，从 Aegle marmelos 叶子中分离出来，在经过验证的 2 型糖尿病动物模型中显示出抗高血糖和抗血脂异常活性。

Aegeline is an alkaloidal-amide isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.?

Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or Bax-expressing cells.Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin.

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Others

Other Targets

Others

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456-12-2

297.3

C18H19NO3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (336.30 mM)

COc1ccc(C(O)CNC(=O)/C=C/c2ccccc2)cc1

N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide

(-20℃)

With Ice Pack

≥ 2 years