ABT-724

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ABT-724 是多巴胺 D4 受体的激动剂（EC50：12.4 nM）。

ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM).

ABT-724 exhibits a selective biochemical profile, as indicates by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors up to a 10 μM concentration. A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT-724 does not inhibit the PDE activity of PDE1, PDE5, or PDE6 at 10 μM concentrations.

ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats. Animal Model:Male adult Wistar rats (~300 g) Dosage:8.8 μg/kg Administration:Subcutaneous injection; daily; for 5 daysResult:Dose-dependently facilitated penile erection.

——

GPCR/G Protein

Dopamine Receptor

D4

——

——

70006-24-5

293.37

C17H19N5

>98% (HPLC)

——

c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1

1H-Benzimidazole 2-((4-(2-pyridinyl)-1-piperazinyl)methyl)-

(-20℃)

With Ice Pack

≥ 2 years