Licarbazepine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

利卡西平是奥卡西平的药理活性代谢物，奥卡西平是一种用于治疗部分性癫痫发作和双相情感障碍的化合物。

Licarbazepine is the pharmacologically active metabolite of oxcarbazepine a drug indicated for the treatment of partial seizures and bipolar disorders.(In Vivo):Eslicarbazepine acetate (ESL) is an oral pro-drug that is rapidly and extensively metabolized by the liver via a hydrolytic first-pass metabolism into S-Licarbazepine, the biologically active drug. The plasma level of the prodrug remains below quantification.ESL is a potent antiepileptic agent with a spectrum of action essentially limited to partial-onset and generalized tonic-clonic seizures. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL works by blocking the voltage-gated sodium channel, which play an essential role in the generation and propagation of the epileptic discharge. ESL is well absorbed after oral administration with a bio-availability about 16% higher than that observed after an equivalent dose of Oxcarbazepine (OXC).

——

Eslicarbazepine acetate (ESL) is an oral pro-drug that is rapidly and extensively metabolized by the liver via a hydrolytic first-pass metabolism into S-Licarbazepine, the biologically active drug. The plasma level of the prodrug remains below quantification. ESL is a potent antiepileptic agent with a spectrum of action essentially limited to partial-onset and generalized tonic-clonic seizures. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL works by blocking the voltage-gated sodium channel, which play an essential role in the generation and propagation of the epileptic discharge.?ESL is well absorbed after oral administration with a bio-availability about 16% higher than that observed after an equivalent dose of Oxcarbazepine (OXC).

Licarbazepine | ?1011-hydroxy-1011 Dihydrocarbamezer

Others

Other Targets

Others

Neurological Disease

Bipolar Disorder

29331-92-8

254.28

C15H14N2O2

>98% (HPLC)

DMSO:3mg/ml(11.7mM)

NC(=O)N1c2ccccc2CC(O)c2ccccc21

10-hydroxy-1011-dihydro-5H-dibenzo[bf]azepine-5-carboxamide

(-20℃)

With Ice Pack

≥ 2 years