Piperaquine tetraphosphate tetrahydrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

四磷酸哌喹四水合物是一种有效的抗寄生虫剂。Piperaquine tetraphosphate tetrahydrate 是一种双喹啉抗疟药，可以与青蒿素联用于抗疟研究。

Piperaquine tetraphosphate tetrahydrate is a potent anti-parasites agent.(In Vivo):Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg?h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg?h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice.

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Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg?h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg?h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice. Animal Model:Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites Dosage:0, 10, 30, 90 mg/kg Administration:A single i.p. administration Result:The median survival time was 10 days at dose of 10 mg/kg.The median survival time was 54 days at dose of 30 mg/kg.All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.Animal Model:Male Swiss mice (6 weeks old)Dosage:90 mg/kg (Pharmacokinetic Analysis)Administration:A single i.p. administration Result:t1/2=17.8 d; AUC=33.5 mg?h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.

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Microbiology/Virology

Parasite

Parasite

Infection

Uncomplicated Plasmodium Falciparum Malaria

915967-82-7

999.6

C29H32Cl2N6.4H3O4P.4H2O

>98% (HPLC)

H2O:6 mg/mL (6.00 mM; Need ultrasonic)

Clc1ccc2c(N3CCN(CCCN4CCN(c5ccnc6cc(Cl)ccc56)CC4)CC3)ccnc2c1.O.O.O.O.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O

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(-20℃)

With Ice Pack

≥ 2 years