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Pyroxamide
CAS No. 382180-17-8
Pyroxamide ( —— )
产品货号. M20956 CAS No. 382180-17-8
Pyroxamide 是一种组蛋白脱乙酰酶 (HDAC) 抑制剂，具有抗肿瘤特性 (HDAC1;IC50: 0.1-0.2 μM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥392 | 有现货 |
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| 10MG | ￥656 | 有现货 |
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| 25MG | ￥1386 | 有现货 |
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| 50MG | ￥2065 | 有现货 |
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| 100MG | ￥2952 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥432 | 有现货 |
|
生物学信息
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产品名称Pyroxamide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Pyroxamide 是一种组蛋白脱乙酰酶 (HDAC) 抑制剂，具有抗肿瘤特性 (HDAC1;IC50: 0.1-0.2 μM)。
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产品描述Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).
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体外实验Cell Viability Assay Cell Line:RD cells; RH30B cells Concentration:1.25-20.0 μM Incubation Time:24 hours; 48 hours; 72 hours Result:Resulted in a cell growth decrease in RD and RH30B cells.Cell Cycle Analysis Cell Line:RD cells; RH30B cells Concentration:10.0 μM; 20.0 μM Incubation Time:48 hours Result:Increased the sub-G1?fractions at 48 hours compared with control samples.
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体内实验——
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同义词——
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC
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研究领域Cancer
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适应症——
化学信息
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CAS Number382180-17-8
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分子量265.31
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分子式C13H19N3O3
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纯度>98% (HPLC)
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溶解度DMSO:125 mg/mL (471.15 mM)
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SMILESO=C(CCCCCCC(=O)Nc1cccnc1)NO
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化学全称N1-hydroxy-N8-(pyridin-3-yl)octanediamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Butler L M Webb Y Agus D B et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide an inhibitor of histone deacetylase[J]. Clinical Cancer Research 2001 7(4):962-970.
