Datelliptium chloride hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Datelliptium 氯化物盐酸盐是一种从玫瑰树碱中提取的 DNA 嵌入剂。具有抗肿瘤活性。

Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.

Datelliptium chloride hydrochloride shows cytotoxic effects after 2 hours of treatment in suspension and primary cultures of rat hepatocytes.

Datelliptium chloride hydrochloride has broad antitumor activity against solid tumors of mice in vivo.Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease.Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210. Animal Model:Mice, colon adenocarcinoma early staged disease model Dosage:170 mg/kg Administration: Intravenous injection, for 12 days Result:Showed potent activity against colon adenocarcinoma.

——

Cell Cycle/DNA Damage

DNA/RNA Synthesis

DNA synthesis

——

——

157000-76-5

434.4

C23H29Cl2N3O

>98% (HPLC)

——

CCN(CC)CC[n+]1ccc2c(C)c3[nH]c4ccc(O)cc4c3c(C)c2c1.Cl.[Cl-]

——

(-20℃)

With Ice Pack

≥ 2 years