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3-chloro-5-hydroxybenzoic Acid
CAS No. 53984-36-4
3-chloro-5-hydroxybenzoic Acid ( —— )
产品货号. M20816 CAS No. 53984-36-4
3-氯-5-羟基苯甲酸 (3-氯-5-羟基 BA) 是 GPR81 的激动剂 (EC50 : 16 μM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥142 | 有现货 |
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| 50MG | ￥228 | 有现货 |
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| 100MG | ￥320 | 有现货 |
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| 200MG | ￥466 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥110 | 有现货 |
|
生物学信息
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产品名称3-chloro-5-hydroxybenzoic Acid
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述3-氯-5-羟基苯甲酸 (3-氯-5-羟基 BA) 是 GPR81 的激动剂 (EC50 : 16 μM)。
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产品描述3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 : 16 μM).
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体外实验3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM).
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体内实验3-Chloro-5-hydroxybenzoic acid (30, 100, and 300 mg/kg; PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks) shows significant reductions in free fatty acids at all doses tested, resulting in a minimum efficacious dose of 30 mg/kg.Pharmacokinetic Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice. Animal Model:C57Bl6/J mice (DIO mice)Dosage:30, 100, and 300 mg/kg Administration:PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks Result:Significant reductions in nonesterified free fatty acid cholesterol (NEFAc) at all doses tested.
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同义词——
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通路Cell Cycle/DNA Damage
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靶点GPR
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受体GPR81
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研究领域——
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适应症——
化学信息
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CAS Number53984-36-4
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分子量172.57
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分子式C7H5ClO3
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纯度>98% (HPLC)
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溶解度DMSO:34mg/mL(197.03mM)
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SMILESO=C(O)c1cc(O)cc(Cl)c1
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化学全称5-Chloro-m-salicylic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Dvorak C A Liu C Shelton J et al. Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects[J]. ACS Medicinal Chemistry Letters 2012 3(8):637-639.
