Belotecan hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Belotecan HydroHClide 是一种合成的水溶性喜树碱衍生物和拓扑异构酶 I 抑制剂，具有潜在的抗肿瘤活性。

Belotecan hydrochloride is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity.(In Vitro):Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC50 values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.(In Vivo):Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.

Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC50 values of9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.

Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.

CKD-602

Cell Cycle/DNA Damage

Topoisomerase

Topo I

Cancer

Non-small cell lung Cancer; Solid tumours

213819-48-8

469.96

C25H28ClN3O4

>98% (HPLC)

DMSO:50 mg/mL (106.39 mM)

CCC1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccccc1c2CCNC(C)C.Cl

(4S)-4-Ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]-ethyl]-1H-pyrano[3'4':67]indolizino[12-b]quinoline-314(4H12H)dione hydrochloride

(-20℃)

With Ice Pack

≥ 2 years