RSV604

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RSV-604 是一种呼吸道合胞病毒 (RSV) 抑制剂，可与 RSV 核蛋白结合 (Kd = 1.31 μM)。

RSV-604 is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM).(In Vitro):RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC50s ranging from 0.5 to 0.9 μM in plaque reduction assay.RSV604 (6 days) inhibits RSV-induced HEp-2 cell death, with an EC50 of 0.86 μM.RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC50 of 1.7 μM.RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency.

RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC50s ranging from 0.5 to 0.9 μM in plaque reduction assay.RSV604 (6 days) inhibits RSV-induced HEp-2 cell death, with an EC50 of 0.86 μM.RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC50 of 1.7 μM.RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency.

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(S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-23-dihydro-1H-benzo[e][14]diazepin-3-yl)urea

Others

Other Targets

RSV

Metabolic Disease

Respiratory syncytial virus infections

676128-63-5

388.39

C22H17FN4O2

>98% (HPLC)

DMSO:195 mg/mL (502.07 mM)

Fc1ccccc1NC(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O

(S)-1-(2-fluorophenyl)-3-(2-oxo-5-phenyl-23-dihydro-1H-benzo[e][14]diazepin-3-yl)urea

(-20℃)

With Ice Pack

≥ 2 years