Galanthaminone ( (-)-Narwedine | Narwedin )

产品货号. M20683 CAS No. 510-77-0

加兰他敏酮是一种胆碱酯酶 (AChE) 抑制剂，用于治疗轻度至中度阿尔茨海默病和各种其他记忆障碍。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥392	有现货
10MG	￥620	有现货
25MG	￥1237	有现货
50MG	￥1981	有现货
100MG	￥2655	有现货
200MG	￥3663	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥548	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Galanthaminone
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

加兰他敏酮是一种胆碱酯酶 (AChE) 抑制剂，用于治疗轻度至中度阿尔茨海默病和各种其他记忆障碍。
产品描述

Galanthaminone is a cholinesterase (AChE) inhibitor?is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
体外实验

Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release.
体内实验

Absorption of Galanthaminone is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.
同义词

(-)-Narwedine | Narwedin
通路

Endocrinology/Hormones
靶点

AChR
受体

AChE
研究领域

——
适应症

——

化学信息

CAS Number

510-77-0
分子量

285.34
分子式

C17H19NO3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 10 mg/mL (35.05 mM)
SMILES

[H][C@]12CC(=O)C=C[C@]11CCN(C)Cc3ccc(OC)c(O2)c13
化学全称

(4aS8aS)-4a59101112-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a32-ef][2]benzazepin-6-one

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Heinrich M Teoh H L . Galanthamine from snowdrop—the development of a modern drug against Alzheimer’s disease from local Caucasian knowledge[J]. Journal of Ethnopharmacology 2004 92(2-3):0-162.

计算器

浓度计算器

摩尔计算器

分子量计算器

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