JOSAMYCIN ( EN-141 )

产品货号. M20653 CAS No. 16846-24-5

JOSAMYCIN 是一种具有抗菌活性的大环内酯类抗生素。交沙霉素与核糖体的解离常数 Kd 为 5.5 nM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
10MG	￥245	有现货
25MG	￥384	有现货
50MG	￥703	有现货
100MG	￥1215	有现货
500MG	￥3042	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥339	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

JOSAMYCIN
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

JOSAMYCIN 是一种具有抗菌活性的大环内酯类抗生素。交沙霉素与核糖体的解离常数 Kd 为 5.5 nM。
产品描述

JOSAMYCIN is a macrolide antibiotic exhibiting antimicrobial activity. The dissociation constant Kd from ribosome for Josamycin is 5.5 nM.(In Vitro):Studies show that the average lifetime on the ribosome is 3 h for Josamycin and that the dissociation constants for Josamycin binding to the ribosome is 5.5 nM. Josamycin slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and completely inhibits formation of the second or third peptide bond, depending on peptide sequence at a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin. At a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin.(In Vivo):Blood and tissue levels of Josamycin after oral administration are 200 mg/kg to rabbits. Tissue levels are generally much higher than the blood levels, and 3 h after the administration, when the blood level is very low, the tissue levels are rather higher than those 1 h after the dose. One hour after the medication, the level in the lungs is the highest of all the tissue levels.
体外实验

Studies show that the average lifetime on the ribosome is 3 h for Josamycin and that the dissociation constants for Josamycin binding to the ribosome is 5.5 nM. Josamycin slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and completely inhibits formation of the second or third peptide bond, depending on peptide sequence at a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin. At a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin.
体内实验

Blood and tissue levels of Josamycin after oral administration are 200 mg/kg to rabbits. Tissue levels are generally much higher than the blood levels, and 3 h after the administration, when the blood level is very low, the tissue levels are rather higher than those 1 h after the dose. One hour after the medication, the level in the lungs is the highest of all the tissue levels.
同义词

EN-141
通路

GPCR/G Protein
靶点

Antibacterial
受体

Bacterial
研究领域

——
适应症

Suppurative streptococcus causes pharyngitis and tonsillitis

化学信息

CAS Number

16846-24-5
分子量

827.99
分子式

C42H69NO15
纯度

>98% (HPLC)
溶解度

DMSO:41.67 mg/mL (50.33 mM)
SMILES

CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)[C@@H]([C@H]1O)N(C)C)OC(C)=O
化学全称

Leucomycin V 3-acetate 4(sup B)-(3-methylbutanoate)

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Eun-Young C So-Hui C Jin-Yi H et al. Josamycin suppresses Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-1β in murine macrophages[J]. Biomedicine & Pharmacotherapy 2018 105:498-505.

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