GS 441524 triphosphate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GS-441524 是 Remdesivir 的主要活性代谢物，活性更优于 Remdesivir ，感染病毒的原代人肺和猫细胞的细胞模型中显示出相似的活性。 GS-441524 对猫传染性腹膜炎病毒 (FIPV) 有较强的抑制作用，对应的 EC50 值为 0.78 μM。

GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.

The cells appear and grow normally at all concentrations of GS-441524 and fail to uptake the fluorescent dye CellTox Green at 24 h. The cytotoxic concentration-50% (CC50) is therefore>100 μM. The effective concentration-50% (EC50) of GS-441524 is calculated to be 0.78 μM.

All 10 treated cats have a rapid response to treatment and lymphocyte levels and rectal temperatures return to pre-infection levels and levels of the two asymptomatic cats. All ten of the once or twice treated cats have remained normal to date (more than eight months post infection). Injections cause a transient "stinging" reaction in some cats within 10 s of compound administration. Localized and transient pain is evidenced by unusual posturing, licking at the injection site and/or vocalizations that last for approximately 30-60 s after injection. Injection reactions are more pronounced in some animals relative to others and reactions are inconsistent from one injection to the next and decreas over time.Remdesivi (IV injection) in NHP results in GS-441524 being present in serum at concentrations 1000-fold higher than Remdesivir throughout a 7-day treatment course.

——

Others

Other Targets

Others

——

——

1191237-69-0

291.26

C12H13N5O4

>98% (HPLC)

In Vitro:?DMSO : 83.33 mg/mL (286.10 mM)

Nc1ncnn2c(ccc12)[C@@]1(O[C@H](CO)[C@@H](O)[C@H]1O)C#N

(2R3R4S5R)-2-(4-aminopyrrolo[21-f][124]triazin-7-yl)-34-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile

(-20℃)

With Ice Pack

≥ 2 years