Sulbutiamine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

舒布硫胺是一种抗氧化剂，通过抑制氧化应激诱导的视网膜神经节细胞死亡而发挥作用。

Sulbutiamine is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death.(In Vitro):Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF.

Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF.

——

Bisibuthiamine

Others

Other Targets

Others

——

——

3286-46-2

702.89

C32H46N8O6S2

>98% (HPLC)

DMSO:75 mg/mL (106.70 mM)

CC(C)C(=O)OCC\C(SS\C(CCOC(=O)C(C)C)=C(\C)N(Cc1cnc(C)nc1N)C=O)=C(/C)N(Cc1cnc(C)nc1N)C=O

[(Z)-4-[(4-Amino-2-methylpyrimidin-5-yl)methyl-formylamino]-3-[[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-(2-methylpropanoyloxy)pent-2-en-3-yl]disulfanyl]pent-3-enyl] 2-methylpropanoate

(-20℃)

With Ice Pack

≥ 2 years