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MS21570
CAS No. 65373-29-7
MS21570 ( —— )
产品货号. M20480 CAS No. 65373-29-7
MS21570 是一种 GPR171 拮抗剂，基于其阻断能力，IC50 为 220 Nm，可减少小鼠的焦虑样行为和恐惧调节。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥440 | 有现货 |
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| 10MG | ￥710 | 有现货 |
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| 25MG | ￥1237 | 有现货 |
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| 50MG | ￥2074 | 有现货 |
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| 100MG | ￥3438 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥781 | 有现货 |
|
生物学信息
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产品名称MS21570
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MS21570 是一种 GPR171 拮抗剂，基于其阻断能力，IC50 为 220 Nm，可减少小鼠的焦虑样行为和恐惧调节。
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产品描述MS21570 as a GPR171 antagonist based on its ability to blockwith an?IC50?of 220 Nmthat reduces anxiety-like behavior and fear conditioning in mice.
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体外实验——
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体内实验MS21570 significantly attenuates this CNO-mediated increase in food intake. Interestingly, MS21570 causes a significant increase in center time compared to vehicle suggesting an effect on the anxiety-like behavior. Intra-BLA administration of MS21570 leads to an increase in open arm time on the elevated plus maze although there is no effect on locomotor activity during this test. Interestingly, when administered before and immediately following fear conditioning, MS21570 significantly attenuates freezing measured 24 hours later. Behavioral differences between systemic and intra-BLA administration of MS21570 could be due to the pharmacokinetic and pharmacodynamic properties of the drug. Further studies are needed to characterize the GPR171 antagonist.
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同义词——
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通路Cell Cycle/DNA Damage
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靶点GPR
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受体GPR171
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研究领域——
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适应症——
化学信息
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CAS Number65373-29-7
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分子量237.34
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分子式C10H11N3S2
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纯度>98% (HPLC)
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溶解度DMSO:125 mg/mL (526.67 mM)
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SMILESCNc1nnc(SCc2ccccc2)s1
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化学全称5-(benzylthio)-N-methyl-134-thiadiazol-2-amine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Bobeck E N Gomes I Pena D et al. The BigLEN-GPR171 Peptide Receptor System within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning[J]. Neuropsychopharmacology 2017.
