MS21570 ( —— )

产品货号. M20480 CAS No. 65373-29-7

MS21570 是一种 GPR171 拮抗剂，基于其阻断能力，IC50 为 220 Nm，可减少小鼠的焦虑样行为和恐惧调节。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥440	有现货
10MG	￥710	有现货
25MG	￥1237	有现货
50MG	￥2074	有现货
100MG	￥3438	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥781	有现货

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生物学信息

产品名称

MS21570
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

MS21570 是一种 GPR171 拮抗剂，基于其阻断能力，IC50 为 220 Nm，可减少小鼠的焦虑样行为和恐惧调节。
产品描述

MS21570 as a GPR171 antagonist based on its ability to blockwith an?IC50?of 220 Nmthat reduces anxiety-like behavior and fear conditioning in mice.
体外实验

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体内实验

MS21570 significantly attenuates this CNO-mediated increase in food intake. Interestingly, MS21570 causes a significant increase in center time compared to vehicle suggesting an effect on the anxiety-like behavior. Intra-BLA administration of MS21570 leads to an increase in open arm time on the elevated plus maze although there is no effect on locomotor activity during this test. Interestingly, when administered before and immediately following fear conditioning, MS21570 significantly attenuates freezing measured 24 hours later. Behavioral differences between systemic and intra-BLA administration of MS21570 could be due to the pharmacokinetic and pharmacodynamic properties of the drug. Further studies are needed to characterize the GPR171 antagonist.
同义词

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通路

Cell Cycle/DNA Damage
靶点

GPR
受体

GPR171
研究领域

——
适应症

——

化学信息

CAS Number

65373-29-7
分子量

237.34
分子式

C10H11N3S2
纯度

>98% (HPLC)
溶解度

DMSO:125 mg/mL (526.67 mM)
SMILES

CNc1nnc(SCc2ccccc2)s1
化学全称

5-(benzylthio)-N-methyl-134-thiadiazol-2-amine

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Bobeck E N Gomes I Pena D et al. The BigLEN-GPR171 Peptide Receptor System within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning[J]. Neuropsychopharmacology 2017.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册