Stachydrine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

水苏碱是中药益母草的主要成分，具有活血化瘀作用。水苏碱可以抑制NF-κB信号通路。水苏碱是食用柑橘类水果的生物标志物。

Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway. Stachydrine is a biomarker for the consumption of citrus fruits.

Stachydrine can inhibit the NF-κB signal pathway, and this may be related to the mechanism of anti-hypertrophic. Intervention of stachydrine significantly suppresses the level of p-IκB protein in the cytosol and NF-κB protein in the nucleus . Tissue factor mRNA is decreased in stachydrine-treated human umbilical vein endothelial cells. Stachydrine attenuates the decline of human umbilical vein endothelial cells viability and the increase of LDH activity induced by anoxia-reoxygenation. A dose dependent decrease in expression of mRNA, and protein levels are observed in stachydrine-treated human prostate cancer cells (PC-3 and LNcaP).

Stachydrine attenuates norepinephrine-induced cardiomyocyte hypertrophy and has potential protective effects against β-adrenergic receptor induced Ca2+ mishandling. Stachydrine treatment reduces the expressions of PERK, CHOP, and caspase-3 in the endoplasmic reticulum stress-related apoptosis pathway.

Proline betaine | L-stachydrine | Methyl hygrate betaine | NN-Dimethyl-L-proline

Apoptosis

NF-κB

p65

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471-87-4

143.18

C7H13NO2

>98% (HPLC)

DMSO:26 mg/mL (181.59 mM);H2O:32 mg/mL (223.49 mM)

C[N+]1(C)CCC[C@H]1C([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years