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Apigenin-7-glucuronide
CAS No. 29741-09-1
Apigenin-7-glucuronide ( Apigenin 7-O-glucuronide )
产品货号. M20261 CAS No. 29741-09-1
Apigenin-7-glucuronide 具有多种活性，包括抗氧化、抗炎和醛糖还原酶抑制活性，它可以抑制 MMP 活性（对于 MMP-3、MMP-8、MMP-9，IC50 值：12.87、22.39、17.52、0.27 μM） ，MMP-13，分别）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥905 | 有现货 |
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| 10MG | ￥1473 | 有现货 |
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| 25MG | ￥2437 | 有现货 |
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| 50MG | ￥3562 | 有现货 |
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| 100MG | ￥4923 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥938 | 有现货 |
|
生物学信息
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产品名称Apigenin-7-glucuronide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Apigenin-7-glucuronide 具有多种活性，包括抗氧化、抗炎和醛糖还原酶抑制活性，它可以抑制 MMP 活性（对于 MMP-3、MMP-8、MMP-9，IC50 值：12.87、22.39、17.52、0.27 μM） ，MMP-13，分别）。
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产品描述Apigenin-7-glucuronide possesses multiple activities including antioxidant anti-inflammatory and aldose reductase inhibitory activities it can inhibit MMP activities (IC50s: 12.87 22.39 17.52 0.27 μM for MMP-3 MMP-8 MMP-9 MMP-13 respectively).(In Vitro):Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively . Scutellarin A also inhibits the migrated capacity of ACHN and 786-O cells in a dose-dependent manner. It is also revealed that after treatment with Scutellarin A (30, 60, and 90 μM) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkably enhanced dose-dependently when compared to the control groups.
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体外实验Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively . Scutellarin A also inhibits the migrated capacity of ACHN and 786-O cells in a dose-dependent manner. It is also revealed that after treatment with Scutellarin A (30, 60, and 90 μM) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkably enhanced dose-dependently when compared to the control groups.
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体内实验——
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同义词Apigenin 7-O-glucuronide
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通路Metabolic Enzyme/Protease
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靶点MMP
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受体MMP-3| MMP-8|MMP-13| MMP-9
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研究领域——
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适应症——
化学信息
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CAS Number29741-09-1
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分子量446.36
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分子式C21H18O11
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纯度>98% (HPLC)
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溶解度DMSO: 50 mg/mL (112.02 mM)
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SMILESO[C@H]1[C@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)cc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Crascì L et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911.
产品手册
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