D 159687

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

D159687 是一种选择性 PDE4D 抑制剂，具有良好的认知功能，因为它可以改善新物体识别测试中的记忆力，但没有抗抑郁或抗焦虑作用。

D159687 is a selective?PDE4D?inhibitorhad a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit.

D159687 (1 μM, 0-24?hours) induces a transient increase in CREB phosphorylation which peaked at 6?hours after treatment.D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1?μM.Western Blot Analysis Cell Line:HT-22 (mouse hippocampal cell line)Concentration:1 μM Incubation Time: 0, 1, 3, 6, 12, 24?hours Result:Induced a transient increase in CREB phosphorylation which peaked at 6?hours after treatment. Western Blot Analysis Cell Line:HT-22 (mouse hippocampal cell line)Concentration:0.01 μM, 0.1 μM, 1 μM Incubation Time:6 hours Result:CREB phosphorylation was optimal at 1?μM.

D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques. Animal Model:Female Cynomolgus macaques (4–6 year old) Dosage:0.05, 0.5, 5 mg/kg Administration:Oral daily for a week Result:A potential recruitment or enhancement of synaptic function with increased task difficulty.

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Angiogenesis

PDE

PDE4D

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1155877-97-6

366.85

C21H19ClN2O2

>98% (HPLC)

DMSO:150 mg/mL?(408.90 mM)

COc1ccc(Cc2ccc(NC(N)=O)cc2)cc1-c1cccc(Cl)c1

[4-[[3-(3-Chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea

(-20℃)

With Ice Pack

≥ 2 years