Prulifloxacin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Prulifloxacin 是一种广谱氟喹诺酮类抗生素。它通过抑制细菌 DNA 拓扑异构酶 II 和 IV 的活性来抑制细菌 DNA 合成。

Prulifloxacin is a broad-spectrum fluoroquinolone antibiotic. It Inhibits bacterial DNA synthesis by inhibiting the activity of bacterial DNA topoisomerase II and IV.(In Vivo):After oral administration of NM441 at a dose of 20 mg/kg to dogs, the peak concentration of NM394 in plasma was 2.39 micrograms/ml, whereas it was 0.63 micrograms/ml for NM394 administered alone. NM441 was as effective as ofloxacin and was twice as effective as ciprofloxacin against systemic infection with Staphylococcus aureus. Against infections with streptococci, NM441 was two to three times as effective as ofloxacin and five times as effective as ciprofloxacin.

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After oral administration of NM441 at a dose of 20 mg/kg to dogs, the peak concentration of NM394 in plasma was 2.39 micrograms/ml, whereas it was 0.63 micrograms/ml for NM394 administered alone. NM441 was as effective as ofloxacin and was twice as effective as ciprofloxacin against systemic infection with Staphylococcus aureus. Against infections with streptococci, NM441 was two to three times as effective as ofloxacin and five times as effective as ciprofloxacin.

NM441 | AF 3012 | Pruvel

Cell Cycle/DNA Damage

Topoisomerase

Topo II| Topo IV

Infection

Acute exacerbations of chronic bronchitis; Bacterial infections; Pneumonia; Respiratory tract infections; Urinary tract infections

123447-62-1

461.46

C21H20FN3O6S

>98% (HPLC)

DMSO: 15 mg/mL (32.5 mM);Water: Insoluble

CC1Sc2c(C(O)=O)c(=O)c3cc(F)c(cc3n12)N1CCN(Cc2oc(=O)oc2C)CC1

6-fluoro-1-methyl-7-(4-((5-methyl-2-oxo-13-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxo-1H4H-[13]thiazeto[32-a]quinoline-3-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years