021-51111890
购物车（）
sales@molnova.cn
Longdaysin
CAS No. 1353867-91-0
Longdaysin ( —— )
产品货号. M20113 CAS No. 1353867-91-0
Longdaysin 是 CK1α 和 CK1δ 的抑制剂 (IC50: 5.6/8.8 μM)。它还可以抑制 ERK2（IC50：52 μM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥426 | 有现货 |
|
| 10MG | ￥677 | 有现货 |
|
| 25MG | ￥1330 | 有现货 |
|
| 50MG | ￥2130 | 有现货 |
|
| 100MG | ￥2997 | 有现货 |
|
| 200MG | ￥4194 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥322 | 有现货 |
|
生物学信息
-
产品名称Longdaysin
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Longdaysin 是 CK1α 和 CK1δ 的抑制剂 (IC50: 5.6/8.8 μM)。它还可以抑制 ERK2（IC50：52 μM）。
-
产品描述Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).
-
体外实验Western Blot Analysis Cell Line:HEK293T cells Concentration:0-50 μM Incubation Time:24 h Result:Reduced the levels of phosphorylated LRP6, total LRP6, phosphorylated DVL2, activated β-catenin, and total β-catenin.
-
体内实验Animal Model:MDA-MB-231 xenografts Dosage:5 mg/kg Administration:i.p., every 3 days for 3 weeks Result:Decreased tumor cell density and proliferation (indicated by Ki-67).Reduced the expression of active and total β-catenin, and decreased the expression of phosphorylated and total LRP6, phosphorylated DVL2, and active and total β-catenin.Reduced mRNA expression of the Wnt target genes including Axin2, DKK1, LEF1, and Survivin.
-
同义词——
-
通路Metabolic Enzyme/Protease
-
靶点Casein Kinase
-
受体CKIα| CKIδ|CDK7|ERK2
-
研究领域——
-
适应症——
化学信息
-
CAS Number1353867-91-0
-
分子量335.33
-
分子式C16H16F3N5
-
纯度>98% (HPLC)
-
溶解度DMSO: 100 mg/mL (298.21 mM);Water: Insoluble
-
SMILESCC(C)n1cnc2c(NCc3cccc(c3)C(F)(F)F)ncnc12
-
化学全称9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Hirota T et al. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol. 2010 Dec 14;8(12):e1000559.
